MyBioSource.com's Phospho-MUC1 (Y1229) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Dot Blot, and ELISA. The Phospho-MUC1 (Y1229) Antibody was generated using CA 15-3, CA15-3, CD227, KL-6, MAM6, MUC1, and Mucin 1 as the antigen and it reacts with Human.
Description
MUC1 is a member of the mucin family and a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas